Nano and Interfacial Catalysis Group

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【Forum for Basic Studies on Energy】(42)
2023-12-22 10:56:03

Asymmetric Outer-Sphere Radical Reactions



简介:国家杰出青年基金获得者。2008年毕业于中国科学技术大学并获得博士学位,2009年-2013年在美国德州大学西南医学中心从事博士后研究,2013年12月加入中国科学院福建物质结构研究所任研究员。主要研究方向为有机合成和不对称催化,发展了新型烷基化试剂,突破了系列难点外球自由基不对称反应,创制了新型荧光母核双苯并[异吼噪化合物,在Nat. Catal., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等杂志发表论文100余篇,申请专利40余项,获得福建省青年科技奖、中国化学会“中国均相催化青年奖”等奖项。国际有机化学杂志Synthesis的副主编,中国化学会有机化学学科委员会委员、应用化学学科委员会委员、工艺化学委员会委员、手性化学学科委员会委员、女化学工作者委员,福州市人大代表、福建省政协委员、中国科协十大代表。

摘要:Notwithstanding the breakthroughs achieved in radical chemistry in last 170 years, control of the stereoselectivity on the untethered and unstrained radical center is still highly challenging due to the high reactivity of radicals. Many radical reactions, including chemical processes in living systems, proceed via the metal-catalyzed outer-sphere mechanism. However, their enantioselectivity is not easily controlled because of the absence of covalent, dative, ionic, and hydrogen bonds that have been traditionally utilized for stereocontrol in previous examples of asymmetric catalysis. Utilizing weak interactions, such as π interactions and van der Waals interactions, we have achieved several asymmetric radical reactions via metal-catalyzed outer-sphere mechanism, affording valuable chiral organic molecules from inexpensive industrial chemical feedstocks.



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